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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
08.01  Cytotoxic drugs
08.01  Side-effects of cytotoxic drugs
08.01  Drugs for cytotoxic-induced side-effects
Calcium Folinate
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Folinic acid 15mg tablet
Folinic acid 10mg/ml injection

 
   
Mesna
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Mesna 400mg tablet
Mesna 600mg tablet
Mesna 100mg/ml injection
 
   
08.01.01  Alkylating drugs
Bendamustine
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NICE Formulary
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Bendamustine Hydrochloride (Levact®) 25mg Injection
For use in line with NICE TA216 (Bendamustine for the first-line treatment of chronic lymphocytic leukaemia)
 
Link  NICE TA216: Bendamustine for CLL
   
Cytotoxic Drug Busulfan
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Busulfan 2mg Tablet 
   
Cytotoxic Drug Chlorambucil
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Chlorambucil 2mg Tablet 
   
Cytotoxic Drug Cyclophosphamide
(Chemotherapy)
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Cyclophosphamide 50mg tablet
Cyclophosphamide 200mg injection
Cyclophosphamide 500mg injection
Cyclophosphamide 1g injection 
   
Cytotoxic Drug Ifosfamide
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Ifosfamide 2g injection 
   
Cytotoxic Drug Melphalan
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Melphalan 2mg tablet 
   
Treosulfan
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Treosulfan 1g injection
Treosulfan 5g injection 
   
08.01.02  Anthracyclines and other cytotoxic antibiotics to top
Cytotoxic Drug Bleomycin
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Bleomycin 15000units injection 
   
Cytotoxic Drug Daunorubicin
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Daunorubicin 20mg injection 
   
Daunorubicin (DaunoXome®)
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Daunorubicin (DaunoXome®) liposomal 50mg injection 
   
Daunorubicin 44mg / Cytarabine 100mg (Vyxeos)
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NICE Formulary
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Daunorubicin 44mg / Cytarabine 100mg (Vyxeos®) powder for concentrate for solution for infusion

 

To be used in line with NICE TA 552: Liposomal cytarabine-daunorubicin for untreated acute myeloid leukaemia

 

 
   
Cytotoxic Drug Doxorubicin Hydrochloride
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Doxorubicin Hydrochloride 10mg injection
Doxorubicin Hydrochloride 50mg injection 
   
Cytotoxic Drug Doxorubicin Hydrochloride (Caelyx®)
(Liposomal)
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Doxorubicin (Caelyx®)Hydrochloride liposomal 50mg injection 
Link  NICE TA91: Ovarian cancer (advanced) - paclitaxel, pegylated liposomal doxorubicin hydrochloride and topotecan (review)
   
Cytotoxic Drug Epirubicin hydrochloride
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Epirubicin hydrochloride 10mg injection
Epirubicin hydrochloride 50mg injection 
   
Cytotoxic Drug Idarubicin Hydrochloride (Zavedos®)
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Idarubicin (Zavedos®) Hydrochloride 5mg capsule
Idarubicin (Zavedos®) Hydrochloride 10mg capsule
Idarubicin (Zavedos®) Hydrochloride 5mg injection
Idarubicin (Zavedos®) Hydrochloride 10mg injection 
   
Cytotoxic Drug Mitomycin
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Mitomycin (Mitomycin C Kyowa®)10mg injection
Mitomycin (Mitomycin C Kyowa®)20mg injection
Mitomycin (Mitomycin C Kyowa®)40mg injection 
   
Mitoxantrone (Onkotrone®)
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Mitoxantrone (Onkotrone®) 25mg in 12.5ml injection 
   
Cytotoxic Drug Pixantrone
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NICE Formulary
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Pixantrone (Pixuvri®) 50mg IV infusion
For use in line with NICE TA306 (Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-Hodgkin's B‑cell lymphoma)
 
Link  NICE TA306: Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-Hodgkin's B‑cell lymphoma
   
08.01.03  Antimetabolites
Cytotoxic Drug Azacitidine (Vidaza®)
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NICE Formulary
High Cost Medicine
Azacitidine (Vidaza®) 100mg injection
For use in line with NICE TA218 (Azacitidine for the treatment of myelodysplastic syndromes, chronic myelomonocytic leukaemia and acute myeloid leukaemia)
 
Link  NICE TA218: azacitidine for myelodysplastic syndromes
   
Cytotoxic Drug Capecitabine
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Formulary
NICE Formulary
Capecitabine 150mg tablet
Capecitabine 500mg tablet
For use in line with NICE TA61 (Guidance on the use of capecitabine and tegafur with uracil for metastatic colorectal cancer)
For use in line with NICE TA191 (Capecitabine for the treatment of advanced gastric cancer)
 
Link  NICE TA100: Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes’ C) colon cancer
Link  NICE TA191: Capecitabine for the treatment of advanced gastric cancer
Link  NICE TA61: Guidance on the use of capecitabine and tegafur with uracil for metastatic colorectal cancer
   
Cytotoxic Drug Clofarabine (Evoltra®)
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Clofarabine (Evoltra®) 20mg infusion 
   
Cytotoxic Drug Cytarabine
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Cytarabine 100mg injection
Cytarabine 1g injection 
   
Cytarabine (DepoCyte®)
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Cytarabine (DepoCyte®) liposomal intrathecal 50mg injection 
   
Cytotoxic Drug Fludarabine Phosphate (Fludara®)
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Formulary
NICE Formulary
Fludarabine (Fludara®) Phosphate 10 mg tablet
Fludarabine Phosphate 50 mg injection
For use in line with NICE TA29: Guidance on the use of fludarabine for B-cell chronic lymphocytic leukaemia
For use in line with NICE TA 119: Fludarabine monotherapy for the first-line treatment of chronic lymphocytic leukaemia 
Link  NICE TA119: Leukaemia (lymphocytic) - fludarabine
Link  NICE TA29: Leukaemia (lymphocytic) - fludarabine
   
Cytotoxic Drug Fluorouracil
(Chemotherapy)
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Fluorouracil 250mg injection
Fluorouracil 500mg injection
Fluorouracil 2.5mg injection
 
   
Fluorouracil
(Efudix)
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Fluorouracil (Efudix®) 5% cream 
   
Cytotoxic Drug Gemcitabine (Gemzar®)
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Formulary
NICE Formulary
Gemcitabine 200mg injection
Gemcitabine 1g injection
For use in line with NICE TA25: Guidance on the use of gemcitabine for the treatment of pancreatic cancer 
Link  NICE TA116: Breast cancer - gemcitabine
Link  NICE TA25: Pancreatic cancer - gemcitabine
   
Cytotoxic Drug Mercaptopurine
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Mercaptopurine (Xaluprine®) 100mg/5ml oral liquid
Mercaptopurine 50mg tablet 
   
Cytotoxic Drug Methotrexate
(Chemotherapy)
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Methotrexate 2.5 tablet
Methotrexate 10mg/5ml oral liquid
Methotrexate 5mg/2ml injection
Methotrexate 50mg/2ml injection
Methotrexate 100mg/2ml injection 
Link  UKMI Q&A: alcohol and methotrexate guidance
Link  UKMI Q&A: What is the clinical significance of the interaction between methotrexate and penicillins? (Oct13)
   
Nelarabine (Atriance®)
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Nelarabine (Atriance®) 250mg infusion 
   
Cytotoxic Drug Pemetrexed (Alimta®)
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NICE Formulary
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Cancer Drugs Fund
Pemetrexed (Alimta®) 500mg injection
For use in line with NICE TA124 (Pemetrexed for the treatment of non-small-cell lung cancer)
For use in line with NICE TA135 (Pemetrexed for the treatment of malignant pleural mesothelioma)
For use in line with NICE TA181 (Pemetrexed for the first-line treatment of non-small-cell lung cancer)
For use in line with NICE TA190 (Pemetrexed for the maintenance treatment of non-small-cell lung cancer)
For use in line with NICE TA309 (Pemetrexed maintenance treatment following induction therapy with pemetrexed and cisplatin for non-squamous non-small-cell lung cancer)
For use in line with NICE TA402 (Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin)
 
Link  NICE TA124: Lung cancer (non-small-cell) - pemetrexed
Link  NICE TA135: Mesothelioma - pemetrexed disodium
Link  NICE TA181: Lung cancer (non-small cell, first line treatment) - pemetrexed
Link  NICE TA190: Lung cancer (non-small-cell) - pemetrexed (maintenance)
Link  NICE TA309: Lung cancer (non small cell, non squamous) - pemetrexed
Link  NICE TA402: Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin
   
Cytotoxic Drug Tioguanine
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Tioguanine 40mg tablet 
   
08.01.04  Vinca alkaloids and etoposide
Cytotoxic Drug Etoposide
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Etoposide (Vepesid®) 50mg capsule
Etoposide (Vepesid®) 100mg capsule 
   
Etoposide (Etopophos®)
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Etoposide (Etopophos®) 100mg injection
Etoposide 100mg/5ml injection
 
   
Vinblastine Sulphate
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Vinblastine Sulphate 10mg injection 
   
Cytotoxic Drug Vincristine Sulphate
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Vincristine Sulphate 1mg injection
Vincristine Sulphate 2mg injection
 
   
Cytotoxic Drug Vinorelbine
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Vinorelbine 10mg/ml injection
Vinorelbine 50mg/5ml injection 
   
08.01.05  Other antineoplastic drugs
Panobinostat  (Farydak®)
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Panobinostat (Farydak®) 10mg hard capsules
Panobinostat (Farydak®) 15mg hard capsules
Panobinostat (Farydak®) 20mg hard capsules
For use in line with NICE TA380 (Panobinostat for treating multiple myeloma after at least 2 previous treatments) 
Link  NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
   
Cytotoxic Drug Atezolizumab (Tecentriq®)
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NICE Formulary
Cancer Drugs Fund

Atezolizumab (Tecentriq®) 1200mg concentrate for solution for infusion

To be used in line with NICE TA492 (Atezolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable)

To be used in line with NICE TA 525 (Atezolizumab for untreated locally advanced or metastatic urothelial carcinoma after platimum-containing chemotherapy)

To be used in line with NICE TA 520 (Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy)

To be used in line with NICE TA 584 (Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancer)

 
   
Axitinib (Inlyta®)
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NICE Formulary
High Cost Medicine
Axitinib (Inlyta®) 1mg tablet
For use in line with NICE TA333 (Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment)  
Link  NICE TA333: Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment
   
Bosutinib (Bosulif®)
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NICE Formulary
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Cancer Drugs Fund
Bosutinib (Bosulif®) 100mg tablet
Bosutinib (Bosulif®) 500mg tablet
For use in line with NICE TA401 (Bosutinib for previously treated chronic myeloid leukaemia)
 
Link  NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
   
Cytotoxic Drug Carfilzomib (Kyprolis®)
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NICE Formulary
High Cost Medicine
Carfilzomib 2mg/ml injection
For use in line with NICE TA457 (Carfilzomib for previously treated multiple myeloma) 
   
Cytotoxic Drug Cemiplimab 350 mg concentrate for solution for infusion (Libtayo®)
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NICE Formulary
High Cost Medicine
NHS England

Cemiplimab (Libtayo) 350 mg concentrate for solution for infusion

For use in line with NICE TA592 Cemiplimab for treating metastatic or locally advanced cutaneous squamous cell carcinoma

 
   
Cytotoxic Drug Ceritinib (Zykadia®)
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NICE Formulary
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Ceritinib 150mg capsules (Zykadia®)
For use in line with NICE TA395 (Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer)

For use in line with NICE TA500 (Ceritinib for untreated ALK-positive non-small-cell lung cancer)

 
Link  NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
   
Dabrafenib (Tafinlar®)
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NICE Formulary
High Cost Medicine
Cancer Drugs Fund
Dabrafenib (Tafinlar®) 50mg capsule
Dabrafenib (Tafinlar®) 75mg capsule
Use in line with NICE TA321 (Dabrafenib for treating unresectable or metastatic BRAF V600 mutation‑positive melanoma)
 
Link  NICE TA321: Dabrafenib for treating unresectable or metastatic BRAF V600 mutation‑positive melanoma
   
Durvalumab (Imfinzi®)
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Formulary
NICE Formulary
High Cost Medicine

Durvalumab (Imfinzi®) 50mg/ml concentrate for solution for infusion 

 

For use in line with NICE TA578 (Durvalumab for treating locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation)

 
   
Cytotoxic Drug Eribulin (Halaven®)
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NICE Formulary
High Cost Medicine
Cancer Drugs Fund
Eribulin (Halaven®) 0.88mg/2ml injection
Eribulin (Halaven®) 1.32mg/3ml injection
For use in line with NICE TA250 (Eribulin for the treatment of locally advanced or metastatic breast cancer)
For use in line with NICE TA423 (Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens)
 
Link  NICE TA250: Breast cancer (advanced) - eribulin
Link  NICE TA423: Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
   
Ibrutinib (Imbruvica®)
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Formulary
NICE Formulary
Ibrutinib (Imbruvica®) 140mg hard capsules
For use in line with NICE TA429 (Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation)


For use in line with NICE TA491 (Ibrutinib for treating Waldernstrom's macroglobulinaemia) 
Link  NICE TA429: Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
   
Idelalisib (Zydelig®)
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Formulary
NICE Formulary
Cancer Drugs Fund
Idelalisib (Zydelig®) 100mg tablet
Idelalisib (Zydelig®) 150mg tablet
For use in line with NICE TA359 (Idelalisib for treating chronic lymphocytic leukaemia) 
Link  NICE TA359: Idelalisib for treating chronic lymphocytic leukaemia
   
Lenvatinib (Kisplyx®)
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Formulary
NICE Formulary
High Cost Medicine

Lenvatinib 4mg capsule

Lenvatinib 10mg capsule

For use in line with NICE TA498 Lenvatinib with everolimus for previously treated advanced renal cell carcinoma 

 
   
Neratinib (Nerlynx®)
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NICE Formulary
High Cost Medicine

Neratinib (Nerlynx) 40 mg film-coated tablets

 

For use in line with NICE TA612 Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumab

 
   
Nintedanib
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Formulary
NICE Formulary
Nintedanib 100mg capsule
Nintedanib 150mg capsule
For use in line with NICE TA347 (Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancer) 
Link  NICE TA347: Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancer
   
Osimertinib (Tagrisso®)
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NICE Formulary
Osimertinib 40mg tablet
Osimertinib 80mg tablet
For use in line with NICE TA416 (Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer) 
Link  NICE TA416: Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer
   
Palbociclib (Ibrance®)
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NICE Formulary

Palbociclib (Ibrance®) 75mg tablets
Palbociclib (Ibrance®) 100mg tablets
Palbociclib (Ibrance®) 125mg tablets
For use in line with NICE TA495 - Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer

For use in line with NICE TA619 - Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer

 
   
Pembrolizumab (Keytruda®)
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Formulary
NICE Formulary
High Cost Medicine

Pembrolizumab (Keytruda®) 50mg injection

For use in line with NICE TA357 (Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab)
For use in line with NICE TA366 (Pembrolizumab for advanced melanoma not previously treated with ipilimumab)
For use in line with NICE TA428 (Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy)
For use in line with NICE TA447 (Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer)

For use in line with NICE TA519 (Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy)

For use in line with NICE TA522 (Pembrolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable)

For use in line with NICE TA531 (Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer)

For use in line with NICE TA553 (Pembrolizumab for adjuvant treatment of resected melanoma with high risk of recurrence)

For use in line with NICE TA557 (Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer)

For use in line with NICE TA600 (Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancer)

 
Link  NICE TA357: Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab
Link  NICE TA366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab
Link  NICE TA428: Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy
Link  NICE TA447: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
   
Ponatinib (Iclusig®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund
Ponatinib (Iclusig®) 15mg tablet
Ponatinib (Iclusig®) 45mg tablet
For use in line with NICE TA451 (Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia) 
Link  NICE TA451: Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
   
Ribociclib tablets (Kisqali®)
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Formulary
NICE Formulary

Ribociclib (Kisqali®) 200mg tablets
For use in line with NICE TA 495 - Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer

For use in line with NICE TA 593 - Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer

 
   
Ruxolitinib (Jakavi®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund
Ruxolitinib (Jakavi®) 5mg tablet
Ruxolitinib (Jakavi®) 15mg tablet
Ruxolitinib (Jakavi®) 20mg tablet
For use in line with NICE TA386 (Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis) 
Link  NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
   
Trametinib (Mekinist®)
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Formulary
NICE Formulary
Trametinib 0.5mg film coated tablets (Mekinist®)
Trametinib 2.0mg film coated tablets (Mekinist®)
For use in line with NICE TA396 (Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma)
 
Link  NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
   
Trifluridine-tipiracil (Lonsurf®)
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On Formulary
Trifluridine-tipiracil 15 mg/6.14 mg film-coated tablets (Lonsurf®)
Trifluridine-tipiracil 20 mg/8.19 mg film-coated tablets (Lonsurf®)
For use in line with NICE TA405 (Trifluridine–tipiracil for previously treated metastatic colorectal cancer)

 
Link  NICE TA405: Trifluridine–tipiracil for previously treated metastatic colorectal cancer
   
Cytotoxic Drug Venetoclax (Venclyxto®)
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Formulary
NICE Formulary
Cancer Drugs Fund

Venetoclax (Venclyxto®) 10mg film-coated tablets

Venetoclax (Venclyxto®) 50mg film-coated tablets

Venetoclax (Venclyxto®) 100mg film-coated tablets

 

To be used in line with NICE TA487 (Venetoclax for treating chronic lymphocytic leukaemia)

To be used in line with NICE TA562 (Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia)

 
   
08.01.05  Amsacrine
08.01.05  Arsenic trioxide to top
08.01.05  Bevacizumab
Bevacizumab (Avastin®)
(Oncology)
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NICE Formulary
High Cost Medicine
Cancer Drugs Fund
Bevacizumab (Avastin®) 1.25mg intra-ocular injection
Bevacizumab (Avastin®) 100mg infusion
Bevacizumab (Avastin®) 400mg infusion
For use in line with NICE TA212 (Bevacizumab in combination with oxaliplatin and either fluorouracil plus folinic acid or capecitabine for the treatment of metastatic colorectal cancer)
For use in line with NICE TA214 (Bevacizumab in combination with a taxane for the first-line treatment of metastatic breast cancer)
For use in line with NICE TA242 (Cetuximab, bevacizumab and panitumumab for the treatment of metastatic colorectal cancer after first-line chemotherapy: Cetuximab (monotherapy or combination chemotherapy), bevacizumab (in combination with non-oxaliplatin chemotherapy) and panitumumab (monotherapy) for the treatment of metastatic colorectal cancer after first-line chemotherapy)
For use in line with NICE TA263 (Bevacizumab in combination with capecitabine for the first-line treatment of metastatic breast cancer)
For use in line with NICE TA284 (Bevacizumab in combination with paclitaxel and carboplatin for first-line treatment of advanced ovarian cancer)
For use in line with NICE TA285 (Bevacizumab in combination with gemcitabine and carboplatin for treating the first recurrence of platinum-sensitive advanced ovarian cancer)


 
Link  NICE TA212: Colorectal cancer (metastatic) - bevacizumab
Link  NICE TA214: Breast Cancer with taxane
Link  NICE TA242: Colorectal cancer (metastatic) 2nd line - cetuximab, bevacizumab and panitumumab (review)
Link  NICE TA263: Breast cancer with capecitabine
Link  NICE TA284: Bevacizumab in combination with paclitaxel and carboplatin for first-line treatment of advanced ovarian cancer
Link  NICE TA285: Ovarian, fallopian tube and primary peritoneal cancer (recurrent advanced, platinum-sensitive or partially platinum-sensitive) - bevacizumab
   
08.01.05  Bexarotene
08.01.05  Bortezomib
Cytotoxic Drug Bortezomib (Velcade®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund
Bortezomib (Velcade®) 3.5mg injection
For use in line with NICE TA129 (Bortezomib monotherapy for relapsed multiple myeloma)
For use in line with NICE TA228 (Bortezomib and thalidomide for the first‑line treatment of multiple myeloma)
For use in line with NICE TA311 (Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantation)

For use in line with NICE TA370 (Bortezomib for previously untreated mantle cell lymphoma)
 
Link  NICE TA129: Multiple myeloma - bortezomib
Link  NICE TA228: Bortezomib and thalidomide for the first-line treatment of multiple myeloma
Link  NICE TA311: Multiple myeloma - bortezomib (induction therapy
Link  NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
   
08.01.05  Brentuximab vedotin
Brentuximab vedotin (Adcetris®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund

Brentuximab (Adcetris®)vedotin 50mg injection
For use in line with NICE TA446 (Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma)
For use in line with NICE TA478 (Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma)

For use in line with NICE TA524 (Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma)

For use in line with NICE TA577 (Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphoma)

 
   
08.01.05  Cetuximab to top
Cetuximab (Erbitux®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund
Cetuximab(Erbitux®) 5mg/ml injection
For use in line with NICE TA 176 (Cetuximab for the first-line treatment of metastatic colorectal cancer)
For use in line with NICE TA439 (Cetuximab and panitumumab for previously untreated metastatic colorectal cancer)
For use in line with NICE TA473 (Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck 
Link  NICE TA118: Colorectal cancer (metastatic) - bevacizumab & cetuximab
Link  NICE TA145: Head and neck cancer - cetuximab
Link  NICE TA172: Head and neck cancer (squamous cell carcinoma) - cetuximab
Link  NICE TA176: Colorectal cancer (first line) - cetuximab
Link  NICE TA242: TA242 Colorectal cancer (metastatic) 2nd line - cetuximab, bevacizumab and panitumumab (review)
Link  NICE TA439: Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
   
08.01.05  Crisantaspase
08.01.05  Dacarbazine and Temozolomide
Cytotoxic Drug Dacarbazine
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Formulary
On Formulary
Dacarbazine 100mg injection
Dacarbazine 120mg injection
Dacarbazine 500mg injection
 
   
08.01.05  Erlotinib
08.01.05  Hydroxycarbamide
Cytotoxic Drug Hydroxycarbamide
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Formulary
On Formulary
Hydroxycarbamide 500mg capsule 
   
08.01.05  Imatinab to top
08.01.05  Ipilimumab
Ipilimumab (Yervoy®)
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Formulary
NICE Formulary
Ipilimumab(Yervoy®) 5mg/ml infusion
For use in line with NICE TA268 (Ipilimumab for previously treated advanced (unresectable or metastatic) melanoma)
For use in line with NICE TA319 (Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma)
 
Link  NICE TA268: Ipilimumab for previously treated advanced (unresectable or metastatic) melanoma
Link  NICE TA319: Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma
   
08.01.05  Mitotane
08.01.05  Panitumumab
08.01.05  Pentostatin
Cytotoxic Drug Pentostatin (Nipent®)
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Formulary
On Formulary
Pentostatin (Nipent®) 10mg injection 
   
08.01.05  Platinum compounds to top
Cytotoxic Drug Carboplatin
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Formulary
On Formulary
Carboplatin 50mg injection
Carboplatin 150mg injection
Carboplatin 450mg injection
Carboplatin 600mg injection 
   
Cytotoxic Drug Cisplatin
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Formulary
On Formulary
Cisplatin 10mg injection
Cisplatin 50mg injection
Cisplatin 100mg injection 
   
08.01.05  Porfimer sodium and temoporfin
08.01.05  Procarbazine
Cytotoxic Drug Procarbazine
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Formulary
On Formulary
Procarbazine 50mg capsule 
   
08.01.05  Protein kinase inhibitors
Cytotoxic Drug Abemaclib ( Verzenios®)
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Formulary
On Formulary
High Cost Medicine

Abemaclib (Verzenios®) 50mg film coated tablets

Abemaclib (Verzenios®) 100mg film coated tablets

Abemaclib (Verzenios®) 150mg film coated tablets

For use in line with NICE TA563: Abemaciclib with an aromatase inhibitor for previously, untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer

 
   
Afatinib (Giotrif®)
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Formulary
On Formulary
High Cost Medicine
Afatinib (Giotrif®) 20mg tablet
Afatinib (Giotrif®) 30mg tablet
Afatinib (Giotrif®) 40mg tablet
Afatinib (Giotrif®) 50mg tablet
For use in line with NICE TA310 (Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer)
 
Link  NICE TA310: Lung cancer (non small cell, EGFR mutation positive) - afatinib
   
Alectinib (Alecensa®)
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Formulary
On Formulary

Alectinib (Alecensa®) 150mg capsules

 

For use in line with NICE TA536: Alectinib for untreated ALK-positive advanced non-small-cell lung cancer

 
   
Cytotoxic Drug Binimetinib (Mektovi®)
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Formulary
NICE Formulary
High Cost Medicine
NHS England

Binimetinib (Mektovi) 15 mg film-coated tablets

 

In line with NICE TA562L Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma

 
   
Cytotoxic Drug Brigatinib (Alunbrig®)
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Formulary
On Formulary
High Cost Medicine

Brigatinib (Alunbrig®) 30mg film coated tablets

Brigatinib (Alunbrig®) 90mg film coated tablets

Brigatinib (Alunbrig®) 180mg film coated tablets

For use in line with NICE TA 571: Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib

 
   
Cytotoxic Drug Cabozantinib (Cometriq®)
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Formulary
NICE Approved
High Cost Medicine
Cancer Drugs Fund
Cabozantinib
For use in line with NICE TA463 (Cabozantinib for previously treated advanced renal cell carcinoma) 
   
Crizotinib (Xalkori®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund

Crizotinib (Xalkori®) 200mg capsule
Crizotinib (Xalkori®) 250mg capsule
For use in line with NICE TA406 (Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer)
For use in line with NICE TA422 (Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer)

For use in line with NICE TA529 (Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer)

 
Link  NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
   
Dasatinib (Sprycel®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund
Dasatinib (Sprycel®) 20mg tablet
Dasatinib (Sprycel®) 50mg tablet
Dasatinib (Sprycel®) 70mg tablet
Dasatinib (Sprycel®) 100mg tablet
For use in line with NICE TA241 (Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia (CML) (part review of NICE technology appraisal guidance 70), and dasatinib and nilotinib for people with CML for whom treatment with imatinib has failed because of intolerance)

For use in line with NICE TA251 (Dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia)
For use in line with NICE TA425 (Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia)
For use in line with NICE TA426 (Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia)

 
Link  NICE TA241: CML for whom treatment with imatinib has failed because of intolerance
Link  NICE TA251: Leukaemia (chronic myeloid, first line) - dasatinib, nilotinib and standard-dose imatinib
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Cytotoxic Drug Encorafenib (Braftovi®)
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Formulary
NICE Formulary
High Cost Medicine
NHS England

Encorafenib (Braftovi) 50 mg hard capsules

Encorafenib (Braftovi) 75 mg hard capsules

In line with NICE TA562: Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma

 
   
Erlotinib (Tarceva®)
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Formulary
NICE Formulary
Erlotinib (Tarceva®) 25mg tablet
Erlotinib (Tarceva®) 100mg tablet
Erlotinib (Tarceva®) 150mg tablet
For use in line with NICE TA374 (Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy)
For use in line with NICE TA227 (Erlotinib monotherapy for maintenance treatment of non-small-cell lung cancer)
For use line with NICE TA256 (Rivaroxaban for the prevention of stroke and systemic embolism in people with atrial fibrillation)
 
Link  NICE TA227: Erlotinib monotherapy for maintenance treatment of non-small-cell lung cancer
Link  NICE TA256: Rivaroxaban for the prevention of stroke and systemic embolism in people with atrial fibrillation
Link  NICE TA374 Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Everolimus (Votubia®)
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Formulary
NICE Formulary
High Cost Medicine
Everolimus (Votubia®) 2.5mg tablet
Everolimus (Votubia®) 5mg tablet
Everolimus (Votubia®) 10mg tablet
For use in line with NICE TA348 (Everolimus for preventing organ rejection in liver transplantation)
For use in line with NICE TA421 (Everolimus with exemestane for treating advanced breast cancer after endocrine therapy)
For use in line with NICE TA449 (Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease)
 
Link  NICE TA348: Everolimus for preventing organ rejection in liver transplantation
Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
Link  NICE TA449: Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
   
Gefitinib (Iressa®)
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Formulary
NICE Formulary
High Cost Medicine
Gefitinib (Iressa®) 250mg tablet
For use in line with NICE TA374 (Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy)
For use in line with NICE TA192 (Gefitinib for the first-line treatment of locally advanced or metastatic non-small-cell lung cancer)  
Link  NICE TA192: Lung cancer (non-small-cell, first line) - gefitinib
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Cytotoxic Drug Imatinib (Gilvec®)
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Formulary
NICE Formulary
High Cost Medicine
Imatinib (Gilvec®) 100mg tablet
Imatinib (Gilvec®) 400mg tablet
For use in line with NICE TA70 (Guidance on the use of imatinib for chronic myeloid leuakaemia)
For use in line with NICE TA209 (Imatinib for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours)
For use in line with NICE TA (Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia (CML) (part review of NICE technology appraisal guidance 70), and dasatinib and nilotinib for people with CML for whom treatment with imatinib has failed because of intolerance)
For ues in line with NICE TA (Dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia)
For use in line with NICE TA326 (Imatinib for the adjuvant treatment of gastrointestinal stromal tumours)
For us in line with NICE TA86 (Imatinib for the treatment of unresectable and/or metastatic gastro-intestinal stromal tumours)
For use in line with NICE TA425 (Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia)
For use in line with NICE TA426 (Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia)
 
Link  NICE TA209: Gastrointestinal stromal tumours (unresectable/metastatic) - imatinib
Link  NICE TA241: Leukaemia (chronic myeloid) - dasatinib, nilotinib, imatinib (intolerant, resistant)
Link  NICE TA251: Leukaemia (chronic myeloid, first line) - dasatinib, nilotinib and standard-dose imatinib
Link  NICE TA326: Imatinib for the adjuvant treatment of gastrointestinal stromal tumours
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
Link  NICE TA70: Leukaemia (chronic myeloid) - imatinib
Link  NICE TA86: Gastro-intestinal stromal tumours (GIST) - imatinib
   
Lapatinib (Tyverb®)
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Formulary
NICE Formulary
High Cost Medicine
Lapatinib (Tyverb®) 250mg tablet
For use in line with NICE TA257(Lapatinib or trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone-receptor-positive breast cancer that overexpresses HER2)
 
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
   
Nilotinib (Tasigna®)
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Formulary
NICE Formulary
High Cost Medicine
Nilotinib (Tasigna®) 200mg capsule
For use in line with NICE TA241 (Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia (CML) (part review of NICE technology appraisal guidance 70), and dasatinib and nilotinib for people with CML for whom treatment with imatinib has failed because of intolerance)
For use in line with NICE TA251 (Dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia)
For use in line with NICE TA425 (Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia)
For use in line with NICE TA426 (Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia)
 
Link  NICE TA241: Dasatinib, nilotinib and high dose imatinib for CML
Link  NICE TA251: Leukaemia (chronic myeloid, first line) - dasatinib, nilotinib and standard-dose imatinib
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Pazopanib (Votrient®)
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Formulary
NICE Formulary
High Cost Medicine
Pazopanib (Votrient®) 200mg tablet
Pazopanib (Votrient®) 400mg tablet
For use in line with NICE TA215 (Pazopanib for the first-line treatment of advanced renal cell carcinoma)
 
Link  NICE TA215: Pazopanib for the first-line treatment of advanced renal cell carcinoma
   
Sunitinib
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Formulary
On Formulary
High Cost Medicine
Cancer Drugs Fund

Sunitinib (Sutent®) 12.5mg capsule
Sunitinib (Sutent®) 25mg capsule

Sunitinib 37.5 mg capsules

Sunitinib 50 mg capsules

 
Link  NICE TA169: Renal cell carcinoma - sunitinib
Link  NICE TA178: Renal cell carcinoma
Link  NICE TA179: Gastrointestinal stromal tumours - sunitinib
   
Cytotoxic Drug Temsirolimus (Torisel®)
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Formulary
On Formulary
High Cost Medicine
Cancer Drugs Fund
Temsirolimus (Torisel®) 30mg infusion 
Link  NICE TA178: temsirolimus for first-line treatment of advanced and/or metastatic renal cell carcinoma
Link  NICE TA207: Mantle cell lymphoma (relapsed) - temsirolimus (terminated appraisal)
   
Vemurafenib (Zelboraf®)
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Formulary
NICE Formulary
High Cost Medicine
Vemurafenib (Zelboraf®)240mg tablet
For use in line with NICE TA269 (Vemurafenib for treating locally advanced or metastatic BRAF V600 mutation‑positive malignant melanoma)  
Link  NICE TA269: Melanoma (BRAF V600 mutation positive, unresectable metastatic) - vemurafenib
   
08.01.05  Taxanes
Cytotoxic Drug Cabazitaxel (Jevtana®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund
Cabazitaxel (Jevtana®) 40mg/ml infusion
For use in line with NICE guidance TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel
 
Link  NICE TA255: Cabazitaxel for prostate cancer
   
Cytotoxic Drug Docetaxel
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Formulary
NICE Formulary
Docetaxel 40mg/ml injection
For use in line with NICE TA101: Docetaxel for the treatment of hormone-refractory metastatic prostate cancer 
Link  NICE TA101: Prostate cancer (hormone-refractory) - docetaxel
Link  NICE TA109: Breast cancer (early) - docetaxel
   
Paclitaxel
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Formulary
NICE Formulary
Paclitaxel 30mg injection
Paclitaxel 100mg injection
For use in line with NICE TA55 (Guidance on the use of paclitaxel in the treatment of ovarian cancer)
For use in line with NICE TA360 (Paclitaxel as albumin-bound nanoparticles in combination with gemcitabine for previously untreated metastatic pancreatic cancer)
 
Link  NICE TA360: Paclitaxel as albumin-bound nanoparticles in combination with gemcitabine for previously untreated metastatic pancreatic cancer
Link  NICE TA55: Guidance on the use of paclitaxel in the treatment of ovarian cancer
   
08.01.05  Topoisomerase I inhibitors to top
08.01.05  Trabectedin
08.01.05  Trastuzumab
Cytotoxic Drug Pertuzumab (Perjeta®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund

Pertuzumab (Perjeta®) 420mg/14ml injection


For use in line with NICE TA424 (Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer)

For use in line with NICE TA569 (Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancer)

 
Link  NICE TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
   
Cytotoxic Drug Trastuzumab (Herceptin®)
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Formulary
NICE Formulary
Trastuzumab(Herceptin®)600mg/5ml injection
For use in line with NICE TA107 (Trastuzumab for the adjuvant treatment of early-stage HER2-positive breast cancer)
For use in line with NICE TA208 (Trastuzumab for the treatment of HER2-positive metastatic gastric cancer)
For use in line with NICE TA257 (Lapatinib or trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone-receptor-positive breast cancer that overexpresses HER)
For use in line with NICE TA34 (Guidance on the use of trastuzumab for the treatment of advanced breast cancer)  
Link  NICE TA107: Breast cancer (early) - trastuzumab
Link  NICE TA208: Gastric cancer (HER2-positive metastatic) - trastuzumab
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
Link  NICE TA34: Breast cancer - trastuzumab
   
Trastuzumab emtansine
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Formulary
NICE Formulary
High Cost Medicine
Trastuzumab emtansine 100mg injection
Trastuzumab emtansine 160mg injection

For use in line with NICE TA371 (Trastuzumab emtansine for treating HER2-positive, unresectable locally advanced or metastatic breast cancer after treatment with trastuzumab and a taxane)
For use in line with NICE TA458 (Tastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxane 
Link  NICE TA371: Trastuzumab emtansine for treating HER2-positive, unresectable locally advanced or metastatic breast cancer after treatment with trastuzumab and a taxane
   
08.01.05  Tretinoin
08.01.05  Vismodegib
Cytotoxic Drug Vismodegib (Erivedge®)
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Formulary
On Formulary
High Cost Medicine
Cancer Drugs Fund
Vismodegib (Erivedge®) 150mg capsule 
   
08.02  Drugs affecting the immune response to top
08.02  Immunosuppressant therapy
08.02.01  Antiproliferative immunosuppressants
Azathioprine
(tablet/injection)
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Formulary
On Formulary
Azathioprine 25mg tablet
Azathioprine 50mg tablet
Azathioprine 50mg injection 
   
Mycophenolate Mofetil
(tablet/capsule/liquid)
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Formulary
On Formulary
High Cost Medicine
Mycophenolate 250mg capsule
Mycophenolate 500 tablet
Mycophenolate 1g/5ml liquid 
   
08.02.02  Corticosteroids and other immunosuppressants
Ciclosporin
(capsule/solution/injection)
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Formulary
On Formulary
Ciclosporin(Neoral)10mg capsule
Ciclosporin(Neoral)25mg capsule
Ciclosporin(Neoral)50mg capsule
Ciclosporin(Neoral)100mg capsule
Ciclosporin(Neoral)100mg/ml solution
Ciclosporin(Sandimmun)50mg capsule
Ciclosporin(Sandimmun)50mg/ml injection
 
   
Tacrolimus
(capsule/MR capsule/ granules)
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Formulary
On Formulary
Tacrolimus 0.5mg capsule(Adoport)
Tacrolimus 1mg capsule(Adoport)
Tacrolimus 5mg capsule(Adoport)
Tacrolimus MR 1mg capsule (Advagraf)
Tacrolimus MR 3mg capsule (Advagraf)
Tacrolimus MR 5mg capsule (Advagraf)
Tacrolimus granules(Modigraf)
Tacrolimus (Prograf) 500micrograms capsules
Tacrolimus (Prograf) 1mg capsules
Tacrolimus (Prograf) 5mg capsules
 
   
08.02.03  Anti-lymphocyte monoclonal antibodies
Alemtuzumab (Lemtrada®)
(injection)
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Formulary
On Formulary
Alemtuzumab(Lemtrada)10mg/ml injection
For use in line with NICE guidelines TA312 (Alemtuzumab for treating relapsing‑remitting multiple sclerosis)  
Link  NICE TA312: Alemtuzumab for treating relapsing‑remitting multiple sclerosis
   
Daratumumab (Darzalex®)
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Formulary
NICE Formulary
High Cost Medicine

Daratumumab (Darzalex®) 20mg/ml concentrate for solution for infusion

For use in line with NICE TA510 - Daratumumab monotherapy for treating relapsed and refractory multiple myeloma

 

For use in line with NICE TA573: Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma

 
   
Gemtuzumab ozogamicin (Mylotarg)
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Formulary
NICE Formulary
High Cost Medicine

Gemtuzumab ozogamicin 5mg injection

 

NICE TA545: Gemtuzumab ozogamicin for untreated acute myeloid leukaemia

 
   
Cytotoxic Drug Obinutuzumab (Gazyvaro ®)
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Formulary
NICE Approved
High Cost Medicine

Obinutuzumab (Gazyvaro®) 1000mg concentrate for solution for infusion


For use in line with NICE TA472 - Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab

For use in line with NICE TA513 - Obinutuzumab for untreated advanced follicular lymphoma

 
   
Ofatumumab (Arzerra®)
(infusion)
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Formulary
NICE Formulary
High Cost Medicine
Ofatumumab(Arzerra)100mg/5ml infusion
For use in line with NICE TA344 (Ofatumumab in combination with chlorambucil or bendamustine for untreated chronic lymphocytic leukaemia)
 
Link  NICE TA202: Chronic lymphocytic leukaemia - ofatumumab
Link  NICE TA344: Ofatumumab in combination with chlorambucil or bendamustine for untreated chronic lymphocytic leukaemia
   
Rituximab (MabThera®)
(injection)
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Formulary
NICE Formulary
High Cost Medicine
Rituximab(MabThera)100mg in 10ml injection
Rituximab(MabThera)500mg in 50ml injection
For use in line with NICE TA65 (Rituximab for aggressive non-Hodgkin's lymphoma)
For use in line with NICE TA137 (Rituximab for the treatment of relapsed or refractory stage III or IV follicular non-Hodgkin's lymphoma)
For use in line with NICE TA174 (Rituximab for the first-line treatment of chronic lymphocytic leukaemia)
For use in line with NICE Guidance,for treatment of Multicentric Castleman's Disease +/- etoposide (individual funding request required)or autoimmune haemolytic anaemia warm type(individual funding request required).
Hyperhaemolysis syndrome (IFR)
Autoimmune haemolytic anaemia
For use in line with NICE TA193 (Rituximab for the treatment of relapsed or refractory chronic lymphocytic leukaemia)
For use in line with NICE TA226 (Rituximab for the first-line maintenance treatment of follicular non-Hodgkin's lymphoma)
For use in line with NICE TA243 (Rituximab for the first-line treatment of stage III-IV follicular lymphoma)
 
Link  NICE TA110: Follicular lymphoma - rituximab Non-Hodgkin's lymphoma - rituximab
Link  NICE TA137: Lymphoma (follicular non-Hodgkin's) - rituximab
Link  NICE TA174: Leukaemia (chronic lymphocytic, first line) - rituximab
Link  NICE TA193: Leukaemia (chronic lymphocytic, relapsed) - rituximab
Link  NICE TA226: Lymphoma (follicular non-Hodgkin’s) - rituximab
Link  NICE TA243: Follicular lymphoma - rituximab (review)
Link  NICE TA308: Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis
Link  NICE TA65: Non-Hodgkin’s lymphoma - rituximab
   
08.02.04  Other immunomodulating drugs to top
Avelumab (Bravencio®)
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Formulary
NICE Formulary
High Cost Medicine

Avelumab 200mg/10ml concentrate for solution for infusion vials

For use in line with NICE TA517 - Avelumab for treating metastatic Merkel Cell Carcinoma

 

 
   
Dimethyl fumarate (Tecfidera®)
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Formulary
NICE Formulary
High Cost Medicine
Dimethyl Fumarate (Tecfidera) 120mg capsule
Dimethyl Fumarate (Tecfidera) 240mg capsule
For use in line with NICE TA320 (Dimethyl fumarate for treating relapsing‑remitting multiple sclerosis)

 
Link  NICE TA320: Dimethyl fumarate for treating relapsing‑remitting multiple sclerosis
   
Fingolimod (Gilenya®)
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Formulary
NICE Formulary
High Cost Medicine
Fingolimod 500mcg capsule
For use in line with NICE TA254 (Fingolimod for the treatment of highly active relapsing–remitting multiple sclerosis)
 
Link  NICE TA254: Fingolimod for highly active relapsing remitting multiple sclerosis
   
Interferon Gamma (Immukin )
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Formulary
On Formulary
Immukin 100micrograms/0.5ml solution for injection vials  
   
Lenalidomide ( Revlimid®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund

Lenalidomide 5mg capsule
Lenalidomide 10mg capsule
Lenalidomide 15mg capsule
Lenalidomide 25mg capsule
For use in line with NICE TA171 (Lenalidomide for the treatment of multiple myeloma in people who have received at least one prior therapy)
For use in line with NICE TA322 (Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality)

For use in line with NICE TA586 (Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomib)

For use in line with NICE TA587 (Lenalidomide plus dexamethasone for previously untreated multiple myeloma)

 
Link  NICE TA171: Multiple myeloma - lenalidomide
Link  NICE TA322: Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality
   
Nivolumab (Opdivo®)
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Formulary
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High Cost Medicine

Nivolumab (Opdivo®) 10 mg/mL concentrate for solution for infusion.

For use in line with NICE TA384 (Nivolumab for treating advanced (unresectable or metastatic) melanoma)
For use in line with NICE TA400 (Nivolumab in combination with ipilimumab for treating advanced melanoma)
For use in line with NICE TA417 (Nivolumab for previously treated advanced renal cell carcinoma)
For use in line with NICE TA462 (Nivolumab for treating relapsed or refractory classical Hodgkin lymphoma)
For use in line with NICE TA483 (Nivolumab for previously treated squamous non-small-cell lung cancer)
For use in line with NICE TA484 (Nivolumab for previously treated non-squamous non-small-cell lung cancer)

For use in line with NICE TA581 (Nivolumab with ipilimumab for untreated advanced renal cell carcinoma)

 
Link  NICE TA384: Nivolumab for treating advanced (unresectable or metastatic) melanoma
Link  NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
Link  NICE TA417: Nivolumab for previously treated advanced renal cell carcinoma
   
Pomalidomide (Imnovid®)
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Formulary
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Cancer Drugs Fund
Pomalidomide 1mg capsule
Pomalidomide 2mg capsule
Pomalidomide 3mg capsule
Pomalidomide 4mg capsule
For use in line with NICE TA338 (Pomalidomide for relapsed and refractory multiple myeloma previously treated with lenalidomide and bortezomib)
For use in line with NICE TA427 (Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib)
 
Link  NICE TA338: Pomalidomide for relapsed and refractory multiple myeloma previously treated with lenalidomide and bortezomib
Link  NICE TA427: Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib
   
Teriflunomide (Aubagio®)
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Formulary
NICE Formulary
High Cost Medicine
Teriflunomide 14mg tablets
For use in line with NICE TA303 (Teriflunomide for treating relapsing–remitting multiple sclerosis)
 
Link  NICE TA303: Teriflunomide for relapsing remitting MS
   
Thalidomide (Celgene®)
(haematology)
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Formulary
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High Cost Medicine
Thalidomide 50mg capsule
For use in line with NICE TA228 (Bortezomib and thalidomide for the first‑line treatment of multiple myeloma)
 
Link  NICE TA228: Bortezomib and thalidomide for the first‑line treatment of multiple myeloma
   
08.02.04  Interferon Alfa
Interferon Alfa (IntronA)
(injection/pen)
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Formulary
On Formulary
High Cost Medicine
Interferon (Intron A) 10MU injection
Interferon (Intron A) 18MU/1.2ml pen
Interferon (Intron A) 30MU/1.2ml pen
 
   
Interferon Alfa (Roferon-A®)
(syringe/cartridge)
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Formulary
On Formulary
High Cost Medicine
Interferon (Roferon A) 3MU/0.5ml syringe
Interferon (Roferon A) 4.5MU/0.5ml syringe
Interferon (Roferon A) 6MU/0.5ml syringe
Interferon (Roferon A) 18MU/0.6ml cartridge
 
   
Peginterferon Alfa
(pen/injection)
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Formulary
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High Cost Medicine
Interferon (Viraferon PEG) 80mcg pen
Interferon (Viraferon PEG) 100mcg pen
Interferon (Viraferon PEG) 120mcg pen
Interferon (Viraferon PEG) 150mcg pen
Interferon Pegylated 80mcg injection
For use in line with NICE TA106: Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis
 
Link  NICE TA106: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA200: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA300: Hepatitis C (children and young people) - peginterferon alfa and ribavirin
Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin and alfa interferon
   
Peginterferon beta-1a (Plegridy®)
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Formulary
On Formulary
High Cost Medicine

Peginterferon beta-1a (Plegridy®) Initiation pack
[Plegridy 63 micrograms solution for injection in pre-filled pen
Plegridy 94 micrograms solution for injection in pre-filled pen]
Peginterferon beta-1a (Plegridy®) 125 micrograms solution for injection in pre-filled pen

 

Use in line with NICE TA624 Peginterferon beta-1a for treating relapsing–remitting multiple sclerosis

 
   
08.02.04  Interferon beta
Interferon beta (Extavia®)
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NHS England

Interferon Beta (Extavia®) solution for injection

For use in line with NICE TA527 (Beta interferon (Extavia) for treating multiple sclerosis)

 
   
08.02.04  Aldesleukin
Aldesleukin (Proleukin®)
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Formulary
On Formulary
High Cost Medicine
Aldesleukin 18MU injection
 
   
08.02.04  Glatiramer acetate
Glatiramer Acetate (Copaxone®)
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Formulary
NICE Formulary
High Cost Medicine
Glatiramer Acetate (Copaxone®) 40mg/ml prefilled syringe
For use in line with NICE TA32: Beta interferon and glatiramer acetate for the treatment of multiple sclerosis 
Link  NICE TA32: Beta interferon and glatiramer acetate for the treatment of multiple sclerosis
   
08.02.04  Natalizumab to top
Natalizumab (Tysabri®)
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Restricted Drug Restricted
NICE Formulary
High Cost Medicine
Natalizumab 300mg/15ml injection
For use in line with NICE TA127: Natalizumab for the treatment of adults with highly active relapsing–remitting multiple sclerosis  
Link  NICE TA127: Multiple sclerosis - natalizumab
   
08.03  Sex hormones and hormone antagonists in malignant disease
08.03.01  Oestrogens
Diethylstilbestrol
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Formulary
On Formulary
Diethylstilbestrol 1mg tablet 
   
Ethinylestradiol
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Formulary
On Formulary
See section 6.4 
   
08.03.02  Progestogens
Medroxyprogesterone Acetate
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Formulary
On Formulary
Medroxyprogesterone acetate 100mg tablet
Medroxyprogesterone acetate 200mg tablet
Medroxyprogesterone acetate 400mg tablet 
   
Megestrol Acetate (Megace®)
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Formulary
On Formulary
Megestrol 160mg tablet 
   
Norethisterone
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Formulary
On Formulary
See section 6.4 
   
08.03.03  Androgens
08.03.04  Hormone antagonists to top
08.03.04.01  Breast cancer
Anastrozole
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Formulary
On Formulary
Anastrozole 1mg tablet 
   
Exemestane
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Formulary
On Formulary
Exemestane 25mg tablet 
   
Fulvestrant (Faslodex®)
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Formulary
NICE Formulary

Fulvestrant 250mg/5ml pre filled injection (Faslodex®)
For use in line with NICE TA239 (Fulvestrant for the treatment of locally advanced or metastatic breast cancer)

For use in line with NICE TA593 (Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer)

 
Link  NICE TA239: Fulvestrant for the treatment of locally advanced or metastatic breast cancer
   
Goserelin (Zoladex®)
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Formulary
On Formulary
Goserelin 3.6mg injection
 
   
Letrozole
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Formulary
On Formulary
Letrozole 2.5mg tablet 
   
Tamoxifen
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Formulary
On Formulary
Tamoxifen 10mg tablet
Tamoxifen 20mg tablet
Tamoxifen 40mg tablet 
   
08.03.04.02  Prostate cancer and gonadorelin analogues
Degarelix (Firmagon®)
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Formulary
NICE Formulary
Degarelix (Firmagon®)80mg powder and solvent for solution for injection
Degarelix (Firmagon®) 120mg powder and solvent for solution for injection
For use in line with NICE TA404 (Degarelix for treating advanced hormone-dependent prostate cancer)
 
Link  NICE TA404: Degarelix for treating advanced hormone-dependent prostate cancer
   
08.03.04.02  Gonadorelin analogues
08.03.04.02  Anti-androgens
Abiraterone (Zytiga®)
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Formulary
NICE Formulary
High Cost Medicine
Cancer Drugs Fund
Abiraterone 250mg tablet (Zytiga®)
For use in line with NICE guidance TA259 (Abiraterone for castration-resistant metastatic prostate cancer previously treated with a docetaxel-containing regimen)
For use in line with NICE guidance TA387 (Abiraterone for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated) 
Link  NICE TA259: Abiraterone for castration resistant prostate cancer
Link  NICE TA387: Abiraterone for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
   
Bicalutamide
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Formulary
On Formulary
Bicalutamide 50mg tablet
Bicalutamide 150mg tablet 
   
Buserelin
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Formulary
On Formulary
Buserelin 100mcg nasal spray
Buserelin 200mcg nasal spray
Buserelin acetate 1mg/ml injection 
   
Cyproterone
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Formulary
On Formulary
Cyproterone 50mg tablet 
   
Enzalutamide (Xtandi®)
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Formulary
NICE Formulary
High Cost Medicine
Enzalutamide 40mg capsule (Xtandi®
For use in line with NICE TA316 (Enzalutamide for metastatic hormone‑relapsed prostate cancer previously treated with a docetaxel‑containing regimen)
For use in line with NICE TA377 (Enzalutamide for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated) 
Link  NICE TA316: Enzalutamide for metastatic hormone‑relapsed prostate cancer previously treated with a docetaxel‑containing regimen
Link  NICE TA377: Enzalutamide for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
   
Flutamide
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Formulary
On Formulary
Flutamide 250mg tablet 
   
Goserelin (Zoladex® LA)
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Formulary
On Formulary
Goserelin acetate 10.8mg LA injection 
   
Leuprorelin Acetate
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Formulary
On Formulary
Leuprorelin3.75mg injection
Leuprorelin 11.25mg injection 
   
Triptorelin
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Formulary
On Formulary
Triptorelin (Decapeptyl SR) 3mg injection
Triptorelin (Decapeptyl SR) 11.25mg injection
Triptorelin (Gonapeptyl) 3.75mg pre filled syringe 
   
08.03.04.03  Somatostatin analogues to top
Octreotide
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Formulary
On Formulary
High Cost Medicine
Octreotide 50mcg/ml injection
Octreotide 100mcg/ml injection
Octreotide 200mcg/ml injection
Octreotide 500mcg/ml injection 
   
Octreotide (Sandostatin Lar®)
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Formulary
On Formulary
High Cost Medicine
Octreotide LAR 10mg injection (Sandostatin Lar®)
Octreotide LAR 20mg injection (Sandostatin Lar®)
Octreotide LAR 30mg injection (Sandostatin Lar®)
 
   
 ....
 Non Formulary Items
Cytotoxic Drug  Dacomitinib film coated tablets  (Vizimpro®)

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Non Formulary
NICE Formulary
High Cost Medicine

Dacomitinib (Vizimpro) 15 mg film-coated tablets

Dacomitinib (Vizimpro) 30 mg film-coated tablets

Dacomitinib (Vizimpro) 45 mg film-coated tablets

 

For use in line with NICE TA595 Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancer

 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

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Formulary  

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NICE approved  

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netFormulary